Study the Association of Nucleotide Polymorphisms in Platelet Receptor and Cytochrome P450 Genes with the Development of Resistance to Antiplatelet Drugs in Patients with Coronary Artery Disease

Aim . To study the association of nucleotide polymorphisms in platelet receptor and cytochrome P450 genes with development resistance to antiplatelet drugs CHD patients. Material Methods The included 243 patients diagnosed after coronary artery bypass surgery (CABG), including 140 acetylsalicylic acid (ASA) treatment group 103 dual therapy (DAT) group. All were tested for aggregation using an optical aggregometer inducers: 5 mM ADP 1 arachidonic (AA). DNA samples analyzed by allele-specific PCR presence rs2046934, rs1126643, rs5918, rs6065, rs4244285 genes. Results No statistically significant differences found during comparison prevalence studied between groups aspirin-sensitive aspirin-resistant patients, as well clopidogrelsensitive clopidogrel-resistant carriage minor major alleles drug was found. In on ASA therapy, carriers C allele T1565C (rs5918) ITGB3 polymorphism had a higher rate AA-induced compared T (18,49±25,92 vs 10,43±17,34, р=0,004). Conclusion. Polymorphisms P2RY12 (rs2046934), ITGA2 (rs1126643), (rs5918), GP1BA (rs6065), CYP2C19*2 (rs4244285) are not associated both ASC DAT. increased activity before CABG.However, C-allele rs5918 gene T-allele carriers.